Table 1

Genotypes and TDT results of the analysed variants in CNR1. NAAA and MGLL in the AN trios

Gene

SNP^1,2

Alleles³ major/minor

Location Exchange

N⁴

Genotypes (%)⁵

Allele frequ.⁶

Transm. rate⁷

p-value⁸

A/A 26 (42.62)

A: 0.64

A/G 26 (42.62)

CNR1

rs2180619

-22,959A/G

Putative promoter

61

G/G 9 (14.75)

G: 0.36

0.49 (G)

1.00

A/A 16 (26.23)

A: 0.55

A/T 35 (57.38)

CNR1

rs806379

-6,274A/T

Intron 2

61

T/T 10 (16.39)

T: 0.45

0.52 (T)

0.90

T/T 43 (70.49)

T: 0.84

T/G 16 (26.23)

CNR1

rs1535255

-6,215T/G

Intron 2

61

G/G 2 (3.28)

G: 0.16

0.50 (G)

1.00

T/T 43 (70.49)

T: 0.84

T/C 16 (26.23)

CNR1

rs2023239

-5,489T/C

Exon 3

Non-coding

61

C/C 2 (3.28)

C: 0.16

0.50 (C)

1.00

G/G 38 (41.76)

G: 0.65

G/A 43 (47.25)

CNR1

rs1049353

1,359G/A

Exon 4

Thr453Thr

91

A/A 10 (10.99)

A: 0.35

0.59 (A)

0.11

G/G 33 (54.10)

G: 0.75

G/A 26 (42.62)

FAAH

rs932816

-272G/A

Putative

promoter

61

A/A 2 (3.28)

A: 0.25

0.39 (A)

0.13

C/C 40 (66.67)

C: 0.80

C/A 16 (26.67)

FAAH

rs324420

10,741C/A

Exon 3

Thr129Pro

60

A/A 4 (6.67)

A: 0.20

0.56 (A)

0.61

G/G 49 (80.33)

G: 0.89

G/A 11 (18.03)

FAAH

rs324419

11,966G/A

Exon 7

Cys299Cys

61

A/A 1 (1.64)

A: 0.11

0.59 (A)

0.52

G/G 60 (98.36)

G: 0.99

G/A 1 (1.64)

FAAH

rs873978

13,883G/A

Intron 7

61

A/A 0 (0.00)

A: 0.01

1.00 (A)

1.00

C/C 34 (56.67)

C: 0.73

C/A 20 (33.33)

FAAH

rs2295632

19,542C/A

3'UTR

60

A/A 6 (10.0)

A: 0.27

0.42 (A)

0.42

G/G 34 (56.67)

G: 0.75

G/A 22 (36.67)

NAAA

rs2292534

368A/G

Intron 1

60

A/A 4 (6.67)

A: 0.25

0.57 (A)

0.42

A/A 38 (62.30)

A: 0.78

A/T 19 (31.15)

NAAA

rs4859567

9,263A/T

Intron 3

61

T/T 4 (6.56)

T: 0.22

0.43 (T)

0.42

G/G 36 (60.00)

G: 0.78

G/T 21 (35.00)

NAAA

rs10518142

19,229G/T

Intron 5

60

T/T 3 (5.00)

T: 0.22

0.63 (T)

0.13

C/C 22 (36.07)

C: 0.61

C/T 31 (50.82)

NAAA

rs6819442

22,995C/T

Intron 9

61

T/T 8 (13.11)

T: 0.39

0.56 (T)

0.42

T/T 36 (59.02)

T: 0.75

T/A 19 (31.15)

MGLL

rs893294

121,143T/A

Intron 8

61

A/A 6 (9.84)

A: 0.25

0.54 (A)

0.75

¹ All SNPs were tested for Hardy-Weinberg equilibrium (exact p ≥ 0.05); ² The TGC haplotype comprises the minor alleles of rs806379, rs1535255, and rs2023239; ³ Numbers are given according to genomic entry AL136096.7 and the translation start codon (nt+1 is the A of ATG); SNP alleles correspond to dbSNP http://www.ncbi.nlm.nih.gov/SNP/ webcite; ⁴ Number of anorexia nervosa trios genotyped; ⁵ Genotype frequencies in the patients with AN; ⁶ Allele frequencies in the patients with AN; ⁷ Transmission rate of the minor alleles; ⁸ for TDT

Müller et al. Child and Adolescent Psychiatry and Mental Health 2008 2:33   doi:10.1186/1753-2000-2-33